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Covid19: Vorschau auf Bewertungen von Studien, Dezember 2020

Foto: H.S.

07.12.2020 - von Rapid Reviews Covid19

Auf der amerikanischen Webseite RAPID REVIEWS COVID19 werden wissenschaftliche Studien rund um das Thema COVID19 begutachtet und bewertet. Im Dezember 2020 hat das Team zur Begutachtung sind wieder etliche Untersuchungen ausgewählt, die das Potential haben könnten, die Kenntnisse über SARS-Cov-2 zu verbessern oder die aufgefallen sind, weil sie als potentiell irreführend gekennzeichnet wurden.
Die folgende Liste präsentiert Forschungsarbeiten über Lufttemperatur und -übertragung, über Triage bei prospektiven Impfstoffen und das immunologische Gedächtnis 6 + Monate nach einer Infektion.

Two peer reviews of the following preprints will be published in the next 10-14 days:

Highlights from the Rapid Reviews Editorial Team
“Role of air temperature and humidity in the transmission of SARS-CoV-2 in the United States” Lower temperatures and humidity positively associated with higher COVID reproduction rate. Analysis of 913 U.S. counties.
15% of cases were attributable to lower humidity, while 5% were attributable to lower temps.

Why we`re excited about this: Given that we are seeing a third wave in cases, and that winter is coming (pun intended), it is really important to understand the effects of climate on the spread of COVID, especially if lower temperature and humidity increase reproduction rate.
This is especially relevant for prisons right now.

“Triage or randomization – who receives a chance of survival in the COVID-19 pandemic crisis?”
Decisions about triage are fundamentally juridical decisions, and thus must be legislated and not handled through professional associations.
Why we`re excited about this: An unusual (and somewhat iconoclastic!) bioethical/legal argument on who should be managing complex ethical decisions about triage.
Will be reviewed by an ethicist.

“SARS-CoV-2 serological tests can generate false positive results for samples from patients with chronic inflammatory diseases”
Of the 20 assays tested, 13 gave false-positive results for samples from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This was most notable in rheumatoid factor (RF)-positive RA samples. Multiple sclerosis (MS) samples did not give any false positive in any of the assays.
Why we`re excited about this: The samples used were negative samples collected before April 2019. These findings reveal the possibility of giving a false indication of protective immunity and obtaining an incorrect picture of the proportion of the population exposed to SARS-CoV-2. On a positive note, this paper tentatively presents appropriate assays for use with patients with RA and SLE (the 7 assays with no false-positive results).

“SARS-CoV-2 antibody signatures for predicting the outcome of COVID-19”
Asserts IgM against ORF7b is an independent predictor of patient survival, and IgG against NSP4, NSP7, NSP9, NSP10, RdRp, NSP14, and ORF3b possess significant predictive power for patient death.
Why we`re excited about this: Understanding early predictors of later severe illness would help focus early intervention to minimize overall morbidity and mortality. IgM Immunological memory to SARS-CoV-2 assessed for greater than six months after infection”

Spike IgG and memory B cells abundant and relatively stable over 6+ months, T cells display half-life of ~3-5 months.
Why we`re excited about this: Understanding length of immune response persistence will help to understand how protective a vaccine or prior infection will be.

Physical Sciences/Engineering

“SARS-CoV-2 infects human engineered heart tissues and models COVID-19 myocarditis”

“Longitudinal physiological data from a wearable device identifies SARS-CoV-2 infection and symptoms and predicts COVID-19 diagnosis”

“CoAID: COVID-19 healthcare misinformation dataset”

“Climatic-niche evolution of SARS-CoV-2"

Biological/Chemical Sciences

“ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication”

“Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago”

“Analysis of the dynamics and distribution of SARS-CoV-2 mutations and its possible structural and functional implications"

Public Health

“Changes in physical activity, sitting and sleep across the COVID-19 national lockdown period in Scotland”

“COVID-19 wastewater epidemiology: A model to estimate infected populations”

“Optimal COVID-19 quarantine and testing strategies”

“Tracking and predicting the African COVID-19 pandemic”

“The role of children in the transmission chain of SARS-CoV-2: a systematic review and update of current evidence”

Social Sciences/Humanities

“Misunderstanding `flattening the curve`”

“Gender-affirming care, mental health, and economic stability in the time of COVID-19: a global cross-sectional study of transgender and non-binary people”

Medical Sciences

“Platelet activating immune complexes identified in COVID-19 associated coagulopathy”

“Human identical sequences of SARS-CoV-2 promote clinical progression of COVID-19 by upregulating hyaluronan via NamiRNA-enhancer network”

“Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets”

“Development of an automated chemiluminescence assay system for quantitative measurement of multiple anti-SARS-CoV-2 antibodies”

Diese Studien und Auswertungen unter: Link

Quelle: Rapid Reviews Covid 19